IntraOp Medical

The clinical results presented for IORT treatment are taken from data published in medical journals or presented at medical and scientific meetings. IORT is always given as part of a comprehensive treatment approach that may also involve additional pre-operative or post-operative radiation therapy or chemotherapy. The appropriate additional therapy that might be required depends on the stage and extent of the disease and is a medical decision that should be made in consultation with a physician.

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For many solid pediatric tumors, IORT can play an important role in the local control of primary or recurrent disease and long-term survival. Included in this group are both malignant and benign, but aggressive, growths such as soft tissue sarcoma, neuroblastoma, WilmÕs tumor, hepatoblastoma and bone sarcoma [1]. IORT is particularly effective when it is a component of a multidisciplinary approach that might include surgery, irradiation and chemotherapy [2].

"Intraoperative Irradiation, Techniques and Results", 1999, p 460

Because children are generally much smaller than adults, there are a number of technical issues to be addressed when IORT is included in the treatment. Particular efforts are made to exclude uninvolved critical growing bones and organs from the high doses of radiation that must often be delivered within a confined space in the body.

REFERENCES
(1) Schomberg et al In, "Intraoperative Irradiation, Techniques and Results". P. 455, Humana Press, 1999
(2) Gunderson eta la, ASTRO Refresher Course No. 211, 1999