The clinical results presented for IORT treatment are taken from data published in medical journals or presented at medical and scientific meetings. IORT is always given as part of a comprehensive treatment approach that may also involve additional pre-operative or post-operative radiation therapy or chemotherapy. The appropriate additional therapy that might be required depends on the stage and extent of the disease and is a medical decision that should be made in consultation with a physician. Go here for a printable version of this page.
Bone sarcomas are rare tumors that most frequently develop in the extremities (1). The goal of surgical treatment, often combined with irradiation, is directed toward control of the cancer while preserving functionality of the affected limb with endoprosthetic devices or bone grafts. Although the number of patients is not large, centers in the U.S., Europe and Japan have included IORT in the treatment (2). The incorporation of IORT at the time of surgery may reduce the need for post surgical external beam irradiation, which can interact with metallic prostheses. IORT also allows direct visualization and precise targeting of the surgical site. Larger radiation doses can be delivered by excluding radiation sensitive normal tissues from the treatment field.
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